GWAS meta-analysis identifies five susceptibility loci for endometrial cancer

D Ramachandran; X Wang; T Laisk; Y Zheng; N Ingold; DM Canson; PF Kho; BJ Naumann; CJ Chapman; K Bousset; AV Krause; P Schürmann; B Wieland; P Hanel; F Hülse; N Häfner; I Runnebaum; N Dubrowinskaja; N Turmanov; T Yugay; ZB Yessimsiitova; F Amant; D Annibali; MW Beckmann; C Bodelon; DD Buchanan; C Chen; MA Clarke; LS Cook; I De Vivo; W De Wispelaere; M Du; DF Easton; J Emons; PA Fasching; CM Friedenreich; G Gallagher; GG Giles; EL Goode; HR Harris; DJ Hunter; DL Kolin; P Kraft; JV Lacey; D Lambrechts; L Lu; GL Mutter; J Naduparambil; K O'Connell; AV Patel; PDP Pharoah; TR Rebbeck; F Ricceri; HA Risch; M Ruebner; C Sacerdote; RJ Scott; VW Setiawan; XO Shu; MC Southey; E Tham; I Tomlinson; C Turman; N Wentzensen; W Xu; H Yu; W Zheng; AB Spurdle; Y Yarden; R Mägi; P Hillemanns; DM Glubb; T Dörk; TA O'Mara

Journal article

GWAS meta-analysis identifies five susceptibility loci for endometrial cancer

D Ramachandran, X Wang, T Laisk, Y Zheng, N Ingold, DM Canson, PF Kho, BJ Naumann, CJ Chapman, K Bousset, AV Krause, P Schürmann, B Wieland, P Hanel, F Hülse, N Häfner, I Runnebaum, N Dubrowinskaja, N Turmanov, T Yugay Show all

Ebiomedicine | Published : 2025

DOI: 10.1016/j.ebiom.2025.105830

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Abstract

Background: Endometrial cancer is the most common gynaecological cancer in high-income countries. In addition to environmental risk factors, genetic predisposition contributes towards endometrial cancer development but is still incompletely defined. Methods: Building on genome-wide association studies (GWASs) by the Endometrial Cancer Association Consortium, we conducted a GWAS meta-analysis of 17,278 endometrial cancer cases and 289,180 controls, incorporating biobank samples from the UK, Finland, Estonia and Japan. Findings: GWAS analysis identified five additional risk loci (3p25.2, 3q25.2, 6q22.31, 12q21.2, and 17q24.2). Corresponding gene-based analyses supported findings for three of t..

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